Growing resistance to antimicrobial substances is a global problem leading to adverse outcomes for patients and increases of costs. The goal of our special lecture SSM 10 Wie verwende ich antiinfektive Substanzen richtig (How do I properly use antimicrobial substances?) is to establish a basis for responsible use of antimicrobial substances and specifically addresses intermediate or advanced medical students. Already existing knowledge is consolidated (e.g., fundamentals of microbiology, pharmacology and antimicrobial therapy), expanded by clinical needs and put into practice (through problem-based learning, discussions of case studies, bedside teaching). The SSM is currently offered once a year in October.